Leadbeater (2003)

Biaryl compounds have a wide range of applications in chemistry, from pharmaceuticals to materials science. Ever since its introduction in 1979 the Suzuki reaction has been a go-to method for generating asymmetric biaryl compounds (among other things). While certainly Nobel Prize material, this synthetic method has its drawbacks, namely the use of a Palladium catalyst. Through careful experimentation and solvent manipulation, our intrepid authors demonstrate that a Suzuki-like cross coupling can be achieved in the absence of Palladium catalyst. All it takes is liberal use of a quaternary ammonium salt, a bit of the old English what-for, and a microwave…


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